Description
Calecim Restorative Hydration Cream
Advanced Stem Cell-Derived Hydration for Dry, Dehydrated and Mature Skin
A deeply hydrating treatment cream powered by PTT-6® — Calecim’s proprietary conditioned media containing stem-cell-derived proteins, growth factors, cytokines and exosomes.
Calecim Professional Restorative Hydration Cream is far more than a conventional moisturiser.
At the heart of the formula is PTT-6®, a proprietary conditioned medium derived from ethically sourced umbilical cord lining stem cells. These stem cells are cultured in the laboratory and then removed, leaving behind the powerful proteins, growth factors, cytokines and exosomes they naturally produce.
The result is a unique stem cell-derived skincare technology designed to support the skin’s natural renewal processes while delivering intensive hydration.
Calecim describes PTT-6® as containing more than 3,000 proteins, including growth factors, cytokines and exosomes that act as biological signals to communicate with skin cells.
The Restorative Hydration Cream combines this regenerative skin-supporting technology with hyaluronic acid, soluble collagen, aloe vera and vitamin E to replenish dry, dehydrated and dull-looking skin.
Diane’s Tip: I often describe Calecim Restorative Hydration Cream as “a treatment in a jar”. What makes it so different from an ordinary moisturiser is the science behind the hydration — you’re not simply adding moisture to the surface of the skin; you’re using a formula containing stem-cell-derived proteins and cell-signalling factors designed to support the skin’s own hydration and renewal processes.
What Makes Calecim Restorative Hydration Cream Different?
It’s not just a moisturiser.
Most moisturisers are designed primarily to add moisture, soften the skin and support the skin barrier.
Calecim Restorative Hydration Cream takes a different approach.
Its key ingredient, PTT-6®, is a stem-cell-derived conditioned medium containing a complex mixture of naturally produced proteins and signalling molecules.
According to Calecim, PTT-6® contains:
- More than 3,000 proteins
- Growth factors
- Cytokines
- Exosomes
- Fibronectins
- Glycoproteins
- Albumin
- Soluble collagen
- Hyaluronic acid
These components are produced by umbilical cord lining stem cells and remain in the conditioned medium after the stem cells themselves have been removed.
Importantly: it does not contain live stem cells
Calecim’s technology uses the messages and proteins produced by the stem cells, rather than putting stem cells into the skincare product.
The stem cells are cultured in a laboratory and removed from the culture medium. What remains is the conditioned medium — PTT-6® — containing the proteins, growth factors, cytokines and exosomes secreted by those cells.
This is the science that sets Calecim apart from a conventional hydrating cream.
What is PTT-6®?
PTT-6® is Calecim’s proprietary cord-lining conditioned media and the signature active technology found throughout the Calecim Professional range.
It originates from epithelial and mesenchymal stem cells found within the lining of the umbilical cord.
Calecim’s parent biotechnology company, CellResearchCorp, developed technology to isolate these stem cells and use their secreted proteins and signalling factors for regenerative research and advanced skincare.
The stem cells are placed into culture and naturally release a complex mixture of substances involved in cellular communication and tissue repair.
Once the stem cells are removed, the remaining conditioned medium contains the substances they produced.
This includes:
Growth factors + cytokines + proteins + exosomes + extracellular matrix components
Together, these are described by Calecim as the “youth messages” of the stem cells — biological signals that communicate with skin cells and support the skin’s natural renewal processes.
Why Are Stem Cell Proteins and Exosomes Important in Skincare?
As we age, the skin’s natural renewal processes become slower and its ability to maintain hydration, collagen, elastin and structural integrity changes.
Stem cells naturally produce signalling proteins and other molecules that communicate with surrounding cells.
Calecim’s technology harnesses these stem-cell-derived signalling factors and incorporates them into PTT-6®.
Calecim states that PTT-6® contains more than 3,000 proteins, including growth factors, cytokines and exosomes, which help signal cells involved in regeneration and renewal.
This is why Calecim is often described as regenerative or bio-signalling skincare, rather than simply another moisturiser.
How Does Calecim Restorative Hydration Cream Work?
Calecim Restorative Hydration Cream works on two important aspects of dehydrated, ageing and stressed-looking skin:
1. It provides immediate hydration
The formula contains hyaluronic acid, aloe vera and other moisturising ingredients to help replenish water and improve the skin’s immediate appearance.
Calecim describes the cream as delivering deep hydration, visible plumping and a dewy appearance.
2. It supports the skin’s own hydration processes
The more unusual aspect of the formula is PTT-6®.
Calecim reports that the proteins, growth factors and exosomes in PTT-6® help support the skin’s own production of hyaluronic acid.
In Calecim’s laboratory testing, PTT-6® was associated with an 83% increase in hyaluronic acid production in the cell-based assay used for the study. This is an in-vitro finding rather than a claim that every user will experience an 83% increase.
This is a key reason why the cream is different from a standard moisturiser:
It doesn’t simply add hydration — it is designed to support the skin’s own hydration mechanisms.
The Science Behind Calecim’s Conditioned Media
From Umbilical Cord Lining Stem Cells to PTT-6®
CellResearchCorp developed patented technology for isolating epithelial and mesenchymal stem cells from the discarded umbilical cord lining of new born deer. According to Calecim, this provides an ethically sourced supply of stem cells without injury to the mother or infant.
These cells are then cultured in controlled laboratory conditions.
During this process, the cells release a complex mixture of:
- Growth factors
- Cytokines
- Exosomes
- Proteins
- Peptides
- Fibronectin
- Glycoproteins
- Collagen
- Albumin
- Hyaluronic acid
The cells themselves are subsequently removed.
What remains is the conditioned medium — PTT-6®.
This is then incorporated into Calecim Professional skincare at carefully calibrated concentrations.
Key Benefits of Calecim Restorative Hydration Cream
Calecim Restorative Hydration Cream is particularly useful for skin that needs hydration plus advanced skin-supporting technology.
It helps to:
- Deeply hydrate dry and dehydrated skin
- Immediately improve the appearance of plumpness
- Smooth the appearance of dehydration lines
- Restore radiance to dull, tired-looking skin
- Improve the appearance of skin texture
- Support the skin’s natural renewal processes
- Support the skin’s own hyaluronic acid production
- Soothe and comfort stressed-looking skin
- Support a healthy-looking skin barrier
- Improve the appearance of mature, dry and fragile-looking skin
- Complement professional aesthetic treatments and post-procedure skincare where appropriate
Calecim specifically positions Restorative Hydration Cream for all skin types, mature skin and post-procedure recovery, with daily AM and PM use recommended.
What is Actually in Calecim Restorative Hydration Cream?
PTT-6® — Cord Lining Conditioned Media
This is the star ingredient.
PTT-6® is a complex of stem-cell-derived proteins, growth factors, cytokines and exosomes, along with components including fibronectin, glycoproteins, albumin, soluble collagen and hyaluronic acid.
It is produced from umbilical cord lining stem cells, but the finished cream does not contain live stem cells.
Hyaluronic Acid
A naturally occurring substance in the skin that attracts and holds water.
Hyaluronic acid helps improve the appearance of plumpness, suppleness and fine lines associated with dehydration.
Calecim states that its PTT-6® technology can support the skin’s own production of hyaluronic acid.
Soluble Collagen
Calecim identifies soluble collagen as one of the components present in its cord-lining conditioned media.
Collagen provides structural support within the skin and contributes to the appearance of firmness and resilience.
Fibronectin
Fibronectin is a naturally occurring glycoprotein involved in the extracellular matrix.
It is one of the stem-cell-derived components identified within PTT-6® and is associated with the structural organisation of skin tissue.
Albumin
Albumin is a naturally occurring protein within PTT-6® for skin turgor (elasticity) and fullness.
Aloe Vera
Aloe vera provides additional moisturising and soothing properties and is particularly useful for skin that feels dry or stressed.
Vitamin E
Vitamin E (tocopherol) provides antioxidant and conditioning benefits while helping support the skin’s moisture-retaining properties.
Calecim Restorative Hydration Cream for Dry and Dehydrated Skin
If your skin feels tight, dry, rough, dull or increasingly difficult to keep hydrated, this is where Restorative Hydration Cream comes into its own.
Calecim describes it as a treatment for dry, dull skin lacking lustre and reports that it delivers deep hydration and visible plumping.
The difference is that hydration is only one part of the formula.
Alongside conventional moisturising ingredients, the cream delivers PTT-6® — a sophisticated stem-cell-derived protein and signalling complex.
This makes it particularly interesting for mature skin where dehydration, reduced radiance and visible signs of ageing often occur together.
Calecim for Mature and Menopausal Skin
As skin matures, it can become drier, thinner-looking and less resilient.
Hormonal changes during peri-menopause and menopause can make these changes even more noticeable, particularly when it comes to dryness, sensitivity and loss of skin comfort.
Restorative Hydration Cream can be particularly useful when the priority is deep hydration and improving the appearance of dry, mature skin.
For a more comprehensive anti-ageing approach, it can also be combined with Calecim Multi-Action Cream.
Explore Calecim Multi-Action Cream →
If you would like help choosing products for menopausal or changing skin, you can also arrange a personalised skincare consultation with Diane Nivern.
Calecim Restorative Hydration Cream After Aesthetic Treatments
Calecim’s stem-cell-derived technology was developed from research into wound healing and tissue regeneration, which is one reason the brand has become associated with post-procedure skincare.
Restorative Hydration Cream can be used as part of a post-procedure skincare routine when appropriate.
However, the timing is important.
Do not apply creams or serums to freshly treated skin unless specifically instructed to do so by your practitioner.
Calecim advises that products should only be applied once skin following an ablative procedure has fully epithelialised.
Always follow the specific aftercare instructions provided by your practitioner.
Who Is Calecim Restorative Hydration Cream For?
This is an excellent choice if your skin is:
- Dry
- Dehydrated
- Tight or uncomfortable
- Dull or lacking radiance
- Mature
- Thin or fragile-looking
- Showing dehydration lines
- Stressed by environmental factors
- In need of intensive hydration
- Recovering following an appropriate aesthetic procedure
It is suitable for all skin types, including mature skin, according to Calecim.
However, Calecim advises avoiding its products when you have active acne.
How to Use Calecim Restorative Hydration Cream
Apply to clean skin morning and evening, gently massaging over the face and extending down past the jawline onto the neck.
For best results, apply your products from the lightest to the heaviest texture.
For a complete Calecim routine:
1. Calecim Professional Serum
The highest concentration of PTT-6® in the Calecim skincare range.
2. Calecim Multi-Action Cream
The more corrective treatment for skin laxity, deeper lines and loss of skin density.
3. Calecim Restorative Hydration Cream
The final moisturising step to deeply hydrate and replenish dry, dehydrated skin.
Calecim specifically recommends applying Multi-Action Cream before Restorative Hydration Cream when both products are being used together.
Shop Calecim Professional Serum →
Calecim Restorative Hydration Cream vs Multi-Action Cream
Both contain Calecim’s PTT-6® technology, but they have different primary purposes.
Restorative Hydration Cream
Best for:
- Dryness
- Dehydration
- Dullness
- Dehydration lines
- Loss of radiance
- Skin needing additional comfort and hydration
Multi-Action Cream
Best for:
- Skin laxity
- Deeper lines and wrinkles
- Loss of skin density
- Loss of firmness
- More advanced visible signs of ageing
Calecim recommends using the two together when additional hydration is required: Multi-Action Cream first, followed by Restorative Hydration Cream.
How Quickly Will I See Results?
You may notice an immediate improvement in hydration and plumpness after application.
Calecim’s product information includes before-and-after results at two weeks and states that the skin’s renewal cycle may take approximately two to four weeks to show results, with optimal results generally observed over a longer period of consistent use.
Results will vary between individuals.
Frequently Asked Questions
Does Calecim Restorative Hydration Cream contain stem cells?
No. It does not contain live stem cells.
Instead, it contains PTT-6® — conditioned media produced by ethically sourced umbilical cord lining stem cells.
The stem cells are removed after being cultured, leaving behind the proteins, growth factors, cytokines and exosomes they have produced.
Does Calecim contain exosomes?
Yes. Calecim states that PTT-6® contains exosomes, growth factors, cytokines and more than 3,000 proteins.
These are produced by the stem cells during the conditioning process and remain in the conditioned media after the cells themselves are removed.
What are the exosomes in Calecim?
The exosomes are part of the complex mixture of biological signalling factors produced by the umbilical cord lining stem cells.
Calecim describes them as part of the cell-signalling system within PTT-6®, helping communicate biological messages to skin cells.
What is PTT-6®?
PTT-6® is Calecim’s proprietary cord-lining conditioned media.
It contains a complex combination of stem-cell-derived proteins, growth factors, cytokines, exosomes and extracellular matrix components.
It is the signature technology behind Calecim Professional skincare.
Is Calecim Restorative Hydration Cream just a moisturiser?
No — and this is one of the most important differences between Calecim and a conventional moisturiser.
It provides hydration through ingredients such as hyaluronic acid and aloe vera, but also contains PTT-6®, the stem-cell-derived conditioned media containing proteins and signalling factors designed to support the skin’s natural renewal and hydration processes.
Is Calecim good for dry mature skin?
Yes. Restorative Hydration Cream is specifically positioned for dry, dull and dehydrated skin and is suitable for mature skin.
Can I use Calecim after an aesthetic treatment?
It may be suitable as part of post-procedure skincare, but the timing depends on the treatment.
Calecim advises that creams, serums and gels should only be applied after the skin has fully epithelialised following an ablative procedure. Always follow your practitioner’s specific aftercare advice.
Can I use Calecim Restorative Hydration Cream with Multi-Action Cream?
Yes.
For skin that needs both corrective anti-ageing support and additional hydration, apply Multi-Action Cream first and Restorative Hydration Cream afterwards.
Why Choose Calecim Professional?
Calecim is unusual because its skincare technology originates from stem-cell and wound-healing research, rather than simply combining conventional cosmetic ingredients.
Its proprietary PTT-6® technology uses the substances naturally secreted by umbilical cord lining stem cells — including proteins, growth factors, cytokines and exosomes — to create a sophisticated cell-signalling skincare ingredient.
This is what makes Calecim particularly interesting for skin that is dry, mature, stressed, fragile or showing visible signs of ageing.
The Diane Nivern Verdict
If your skin needs more than a standard moisturiser, Calecim Restorative Hydration Cream is in a different category.
Yes, it hydrates.
Yes, it makes skin feel softer and look plumper.
But the real USP is what is delivering that hydration.
At its heart is PTT-6® — a proprietary conditioned medium derived from umbilical cord lining stem cells, containing a complex mixture of stem-cell-derived proteins, growth factors, cytokines and exosomes.
It is this combination of advanced stem cell science + intensive hydration that makes Calecim Restorative Hydration Cream so different.
For dry, dehydrated, mature or stressed skin, it is one of the most interesting treatment moisturisers I recommend.
Shop Calecim Restorative Hydration Cream →
Complete Your Calecim Routine
Calecim Professional Serum
Calecim’s most concentrated topical PTT-6® product, designed for thin, sensitised, ageing and post-procedure skin.
Explore Calecim Professional Serum →
Calecim Multi-Action Cream
The more corrective Calecim cream for skin experiencing loss of firmness, elasticity, density and deeper lines.
Explore Calecim Multi-Action Cream →
Personalised Skincare Advice
Not sure which Calecim product is right for you?
Additional information
| Size | 50g Pump, 20g Try-Me Size, Clearance Special Offers |
|---|
Product Ingredients
Aqua, Aloe Barbadensis Leaf Juice, Oleic Acid, 1,2-Hexanediol, Cetyl Alcohol, Glycoproteins, Cetearyl Alcohol, Glyceryl Stearate, Linoleic Acid, Soluble Collagens, Peg-40 Stearate, Palmitic Acid, Ceteareth-20, Albumin, Stearic Acid, Fibronectins, Tocopherol, Fragrance, Potassium Lactate, Disodium Edta, Hyaluronic Acid, Lactic Acid, Limonene, Citric Acid, Potassium Sorbate, Sodium Benzoate.
How to Use
For optimal effects, use CALECIM Professional Restorative Hydration Cream as part of a daily skincare routine.
Apply the cream after cleansing and the application of a corrective cream like CALECIM Professional Multi-Action Cream.
To use, dot small amounts of cream over the face and lightly pat into the skin. Make sure to cover all areas of the face, all the way back to the skin in front of the ears and up to the eyelashes of the lower eyelid.
How long will the treatment take?
Use this cream daily in the morning and evening for best results. If used as recommended, visible improvements will be apparent after 2 weeks of use with optimal effects seen after 90 days.
What can I use it for?
CALECIM Professional Restorative Hydration Cream plumps and hydrates skin from within. Use it as part of a regular skincare regimen to combat the signs of aging and bring radiance back to the skin.
What areas should I use this product on?
This facial cream is suitable for use on all areas of the face, neck and decollete. Use only on healthy, unbroken skin.
ORDERING & RETURNS POLICY
Delivery costs are included for UK addresses only - additional costs will be chargeable for delivery outside the UK Delivery via Royalmail “Tracked 48” service – You will receive email and text delivery notifications from RoyalMail once we process your order - please ensure you provide accurate information when placing your order as those details generate your delivery and tracking information We will not be held responsible for loss of parcels as a result of inaccurate or incomplete delivery address information provided by you at the time of ordering. Additional postage fees will be incurred for delivery outside of the UK – we will contact you & quote the additional postage costs;Refunds & Cancellations
You have the right to cancel your order and return products unused, unopened (product seals must be intact) and in their original undamaged packaging within 14 days of placing your order Please Note: If you decide to cancel your order after you’ve made your PayPal transaction but before we have despatched the products we will honour your cancellation and refund in full less the non-refundable Paypal transaction fees which PayPal deduct from your payment currently 3.4% of the payment you've made. If you cancel your order after we’ve despatched your products we'll refund your order, less postage fee of £3.99, less the non-refundable PayPal fees which are currently 3.4% of the payment you’ve made when we receive the returned products which must be unopened, seals intact, unused and in all original packaging Please email us on therapy@dianenivern.com or call 01617961169 (Monday to Saturday) if you wish to cancel your order and return it - You will be responsible for the costs of returning the product you wish to return If you have a complaint regarding the product or experience an allergic reaction to the product please call us on 01617961169 or email therapy@dianenivern.com Please bear in mind that our skincare products are cosmeceutical grade – not cosmetic – they have “active” ingredients. Some degree of “downtime”, mild irritation, dryness or flakiness may be experienced and should not be considered as an “allergic reaction” – Please contact us for guidance before returning your product In the event of an allergic reaction there must be no more than 10% of product used to be refunded. You must be willing to provide details and photographic evidence of the issue as we are obliged to report skin reactions to the product’s manufacturerShip your item back to Us
Returns address: 406 Bury New Road, Whitefield Manchester, M45 7SX, UK Please remember to ensure that the item you are returning is repackaged with all original elements.Related Products
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Diane Nivern Clinic Gift Voucher £25
Gift Voucher £25
Give the gift of fabulous skin to friends & family with a Diane Nivern Clinic Gift Voucher
Our beautiful gift vouchers are presented in a gold or silver envelope
Available for any value they are redeemable against any of our facial skincare & aesthetic treatments and our skincare products
May be used as a way to save up for some of our premium treatments
Redeemable for products or in clinic treatments
Presented in a gold or silver envelope
or Can be emailed as a Virtual Gift Voucher
We can add a personal message if you'd like us to send as a gift
Valid for six months from date of purchase
Non Refundable
Also available in £100 Gift Voucher & £50 Gift Voucher
